bijwerkingen clozapine

Table 10. Adverse Reactions (≥2%) Reported in CLOZARIL-treated Patients (N=842) Across all CLOZARIL Studies (excluding the 2-year InterSePTTM Study)

Body System Adverse Reaction*

CLOZARIL

N=842

Percentage of Patients

Body System Adverse Reaction*

Central Nervous System:

1. Drowsiness/Sedation 39
2. Dizziness/Vertigo 19
3. Headache 7
4. Tremor 6
5. Syncope 6
6. Disturbed Sleep/Nightmares 4
7. Restlessness 4
8. Hypokinesia/Akinesia 4
9. Agitation 4
10. Seizures (convulsions) 3†
11. Rigidity 3
12. Akathisia 3
13. Confusion 3
14. Fatigue 2
15. Insomnia 2

Cardiovascular:

16. Tachycardia 25†
17. Hypotension 9
18. Hypertension 4

Gastrointestinal:

19. Constipation 14
20. Nausea 5
21. Abdominal Discomfort/Heartburn 4
22. Nausea/Vomiting3
23. Vomiting 3
24. Diarrhea 2

Urogenital:

25. Urinary Abnormalities 2

Autonomic Nervous System:

26. Salivation 31
27. Sweating 6
28. Dry Mouth 6
29. Visual Disturbances 5

Skin:

30. Rash 2

Hemic/Lymphatic:

31. Leukopenia/Decreased WBC/Neutropenia 3

Miscellaneous:

32. Fever 4
33. Weight Gain 5

†Rate based on population of approximately 1700 exposed during premarket clinical evaluation of CLOZARIL.

home - manual - source - about